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Named for its ability to promote slow-wave (delta) sleep in experimental animals, DSIP has been studied for its roles in sleep regulation, stress response, and pain modulation

For example reactions requiring GSH as a key cofactor are catalyzed by the prostaglandin H synthase, the rate-limiting enzyme in the production of prostaglandins and thromboxane [25], which are essential regulators of vascular function

Indoleamine-2,3-dioxygenase 1 deficiency suppresses seizures in epilepsy

Preclinical rationale for developing MEK inhibition as a therapeutic strategy in acute myelogenous leukemia

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He also hypothesized that senolytic drugs can selectively eliminate senescent cells from patients with SLE and rejuvenate these tissues, improve organ function, and promote disease dormancy