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Minchin et al

Cytochrome P450 enzymes contributing to demethylation of maprotiline in man

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Additional class-related considerations based on experience with similar incretin-based medicines include: Pancreatitis: Seek urgent medical attention for severe or persistent abdominal pain, particularly if it radiates to the back Gallbladder disease: Report any yellowing of the skin or eyes (jaundice), or upper right abdominal pain Hypoglycaemia: People taking retatrutide alongside insulin or a sulfonylurea may be at increased risk of low blood sugar

Thats a gap patients should be aware of

Both focus on FDA-approved medications (Wegovy, Zepbound)