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Subsequent reperfusion triggers an abrupt overproduction of ROS, including hydrogen peroxide, superoxide anion, hydroxyl radical, singlet oxygen, hypochlorous acid, and nitric oxide 33 , amplifying oxidative stress and aggravating tissue injury

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Nasr, I.W., Reel, M., Oberbarnscheidt, M.H., Mounzer, R.H., Baddoura, F.K., Ruddle, N.H

PubMed Central , Clinical, Cosmetic and Investigational Dermatology , vol