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We evaluated the expression levels of M1 (CD86+) and M2 (CD206+) markers in vitro through immunofluorescence staining and flow cytometry assays to investigate whether LAbs@Lip@BMn/Rapa treatment can convert LPS-stimulated BV2 cells from pro-inflammatory M1 phenotypes into anti-inflammatory M2 phenotypes

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When combined with Ipamorelin in dual-pathway research models, the two compounds engage both the cAMP pathway via GHRHR and the calcium signalling pathway via GHS-R1a simultaneously on the same somatotroph cell population producing a synergistic GH pulsatility profile that neither compound achieves independently

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Tirzepatide, which activates both GLP-1 and GIP receptors, may produce different effects compared to pure GLP-1 agonists