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Gene expression shifts from tissue destruction to repair patterns with 127 genes altered, upregulating repair genes while downregulating inflammatory genes

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Lieber, 2003

Another two CML lines have much higher levels of GSH and are insensitive to the combinatory treatment of JMF4073 and UK-5099, because UK-5099 treatment was unable to reduce GSH and induce replication stress

Genetic factors affecting receptor expression or downstream signaling may limit effectiveness

PubMed , Biomedical Reports , vol