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Mayo Foundation for Medical Education and Research (MFMER)

The histidine imidazole and the N-terminal amine and lysine side chain give GHK a high intrinsic affinity for copper(II), and as the free apo-peptide it has been studied in preclinical and in vitro research as a copper-binding ligand and as a signaling molecule implicated in extracellular-matrix remodeling, collagen and metalloproteinase regulation, and antioxidant and anti-inflammatory gene-expression pathways

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Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex GHK. FEBS Letters , 238(2), 343346

10.1074/jbc.M105395200 J

Neurobiol Dis 94:169178 Miotto G, Rossetto M, Di Paolo ML, Orian L, Venerando R, Roveri A et al (2020) Insight into the mechanism of ferroptosis inhibition by ferrostatin-1