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Proven Cognitive Agents How to Read a Peptide COA and Dose Correctly What a credible COA must include: HPLC purity of 98 percent or above (confirms the dominant peak is the target compound) Mass spectrometry (ESI-MS or MALDI) confirmation matching the expected molecular weight (this is what confirms correct sequence, not just purity) Residual solvent testing per ICH Q3C guidelines Endotoxin (LAL test) below 1 EU per mg for injectable-grade material Lot number traceable to the synthesis batch A COA listing only HPLC purity cannot confirm that the dominant peak is the correct peptide rather than a related impurity with similar retention time

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Neuron 19 , 893901 (1997)

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