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Intramuscular B12 injections, rather than oral B12 supplements, help correct the deficiency

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Routes of Drug Administration Chapter 6 Giovannitti JA, Trapp LD (1991) Adult sedation: oral, rectal, IM, IV

BacteriostaticWater Injection, USP is sterile, for injection

However, long-term human studies specifically examining extended use remain limited

Intrinsic factor, a protein that shuttles B12 through the absorption process, becomes saturated after a meal containing an above-average amount of B12 and about 4 to 6 hours are required before it can efficiently absorb another dose (IOM, 1998)