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Possible Side Effects and Considerations While GLP-1 drugs for weight loss are effective, they do come with potential side effects

Y., Cao, S

1 Heart failure with preserved ejection fraction (HFpEF) now accounts for approximately half of all HF cases, particularly among older adults, and is strongly associated with comorbid conditions such as hypertension, type 2 diabetes mellitus, atrial fibrillation, and obesity

The comparison is useful because many researchers transition from semaglutide or tirzepatide to retatrutide, and understanding relative dose equivalences helps inform that decision

& de Lartigue, G

Semaglutide: first global approval