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The STEP 1 trial, published in the New England Journal of Medicine , enrolled 1,961 adults with obesity and found that participants receiving semaglutide 2.4 mg weekly lost an average of 14.9% of their body weight over 68 weeks, compared to 2.4% in the placebo group (4)

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GLP-1 receptors are widely distributed throughout the gut, and their activation slows gastric emptying the rate at which food moves from the stomach into the small intestine

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