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Hu et al., 2024)

Specifically, the aromatic indole ring of melatonin acts as a buffer and scavenges reactive oxygen species (ROS) and nitrogen species (RNS)

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by transplanting fecal communities from clinically verified responder or non-responder human phenotypes into germ-free rodent models, investigators can systematically isolate and verify the causal contribution of specific microbial configurations to incretin drug efficacy

It has also been used successfully for the treatment of acute respiratory distress syndrome at a dose of 150mg/kg on day one followed by 50mg/kg for 3 days, with efficacy in part determined by GST polymorphisms