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These effects were blunted in CNS-specific GIPR knockout mice, suggesting a key role of CNS GIPR in the control of energy metabolism (138) ( Figure 1 Section C)

Now, a GLP-1 can replace metformin (with, for some, fewer side effects) or be taken together with metformin not only for the treatment of type 2 diabetes but also off-label for weight management

Physical activity level

compared to a low bioavailability of 1-2% when taken orally

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