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270 LPS as an endotoxin exists in the cellular wall of gram-negative microbes that generates endotoxaemia, elicits an extensive immunological response and activates adaptive immune cells, 271 such as B and T cells, which can serve as sensors of bacterial, present within the gut, convey signals to the enteric neural system and result in alterations to ENS

However, this still leaves two thirds of the heart benefits of semaglutide unexplained

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In human brain microvascular endothelial cells, downregulating hypoxia-inducible factor-1 activity and inhibiting its downstream gene vascular endothelial growth factor ameliorates the increased paracellular permeability and the alterations of distribution pattern of occludin and zonula occludens-1 induced by high glucose level [75]

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