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These molecules activate immune-sensing pathways in microglia, including TLR4, P2X7, and cGASSTING, leading to the robust release of pro-inflammatory cytokines such as interleukin-1 (IL-1) and tumor necrosis factor- (TNF-) (Ayton et al., 2013)

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Specifically, spliceosome activation during the B to B act transition depends on phosphorylation of the U2 snRNP component SF3B1 by the CDK11-cyclin L-SAP30BP complex

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