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ACKNOWLEDGEMENTS This work was supported by grants from the National Institutes of Health Grants (R01HL094722 and R01DK102359 to Z.L., and F32DK121431 to K.L.) and the American Diabetes Association (1-17-ICTS-059) (to Z.L.)

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Semaglutide itself does not make you cold, but some of the medications intended effects such as weight loss and metabolic changes can cause some people to temporarily feel colder