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Methods Subjects Adult male and female LongEvans rats (Envigo-Harlan, Indianapolis, IN) were delivered at 7 weeks old and housed in same-sex pairs in ventilated cages

GLP-1RAs have been shown to exert beneficial effects on the maintenance of endothelial integrity

Beyond 12 months Clinical trials for both Mounjaro and Wegovy show continued weight loss beyond 12 months at therapeutic doses, with average total weight loss of 20 to 22% for tirzepatide 15mg and 14 to 15% for semaglutide 2.4mg at the end of 72-week and 68-week trials respectively

Insulin and leptin levels drop precipitously, both of which have downstream effects on follicular health

If you do drink, do so with food, slowly, and in moderation and never on an empty stomach

Those who build strong habits along the way are much better positioned to succeed when the medication is discontinued