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The SUSTAIN-6 trial , published in the New England Journal of Medicine in 2016, found that participants taking semaglutide had a higher rate of diabetic retinopathy complications compared to placebo (3.0% versus 1.8%)

Week 1: The "Quiet" Phase For most, the first week is about adaptation rather than weight loss

[DOI] [PMC free article] [PubMed] [Google Scholar] 26.Aminlari A., East M., Wei W., Quillen D

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GLP-1 therapies have been shown to reduce caloric intake by up to 39% and produce substantial weight loss