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Potential for significant weight loss, averaging 15-20% of initial body weight, supported by medication and healthy habit reinforcement

This increases cellular sensitivity to growth hormone and downstream IGF-1 signaling, which drives collagen synthesis and extracellular matrix remodeling the biological foundation of tendon repair

n = 16 for Kcnj11 fl/fl mice)

The 4-step dose escalation protocol minimizes these effects

Dietary supplementation with marine-derived n-3 PUFAs has been shown to exert anti-inflammatory effects in metabolic disorders