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Supercooled storage at -4 C showed markedly lower hemolysis than -8 C, preserved adenylate pools, decreased glucose consumption, and reduced lactate accumulation and pentose phosphate pathway activation

Furthermore, the release of ASP and BBR upon disulfide bond cleavage enhances the tumor inhibitory efficacy of ASP-BBR-PM@HNK, indicating a more pronounced anti-tumor potential relative to previous analogous studies 47,48

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