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This increased risk is attributed to diabetic peripheral neuropathy, which shares overlapping symptoms with RLS and may complicate diagnosis

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When this conversion step is impaired, the MTR pathway slows, homocysteine accumulates, and SAM-e regeneration decreases

Cancer Res 54 : 22182222 Resnicoff M, Tjuvajev J, Rotman HL, Abraham D, Curtis M, Aiken R, Baserga R (1996) Regression of C6 rat brain tumors by cells expressing an antisense insulin-like growth factor I receptor RNA

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The angiogenic action appears tied to T4s actin-binding motif: Philp et al., FASEB J 2003 demonstrated that this seven-residue site is essential for promoting endothelial migration and vessel formation