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MacDonald PE, El-kholy W, Riedel MJ, Salapatek AMF, Light PE, Wheeler MB

Clinical evidence indicates substantial decreases in hepatic fat accumulation before the onset of severe illness, with studies documenting alanine transaminase (ALT) normalisation in 40% of individuals exhibiting baseline increases (Buse et al

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Brain insulin resistance may indeed play a role in the pathophysiology of cognitive disorders, and addressing this may be a mechanism through which GLP-1RAs act pro-cognitively 35

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