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To withstand the potential cytotoxic effects brought by this unexceptionally high level of ROS, cancer cells are capable to regulate ROS levels by modulating the cellular antioxidant production, which allows them to adapt to oxidative stress and thus ensures their sustainable propagation [2]

Consequently, Ng et al

2023 Apr;37(4):1330-1345

If the frequency and cost criteria thresholds for a complexity adjustment are met and reassignment to the next higher cost APC in the clinical family is appropriate (based on meeting the criteria outlined above), we make a complexity adjustment for the code combination

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