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L cell secretagogues Stimulation of GLP-1 secretion from enteroendocrine L cells is another approach that may be able to realise the therapeutic potential of GLP-1, perhaps in combination with DPP-4 inhibition to prevent the inactivation of the GLP-1 released

For example, nicotine patches help with smoking cessation, whereas fentanyl patches deliver controlled doses for pain relief

Practical Considerations Identifying patients who can benefit from GLP-1 RAs remains in the hands of the clinician

Suspected side effects should be reported to the MHRA via the Yellow Card scheme (yellowcard.mhra.gov.uk)

2 Currently approved GLP-1 drugs for chronic weight management include Saxenda, which is a once-daily injection, and Wegovy and Zepbound, which are once-weekly injections

The People with symptoms or a diagnosis of ME/CFS should not follow any type of activity plan without discussing it with their doctor first