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In fact, high levels in the blood may reflect that the folate is not being properly utilized by the body

Many enzymes of DNA replication and repair (helicases, nucleases, glycosylases, demethylases) and ribonucleotide reductase use Fe as an indispensable cofactor for functioning (92)

When it is used in the evening, it often lines up with the body's normal nighttime peak

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Neurology 1991;41:1726-32

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