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Trial exclusion patterns Phase 2 and Phase 3 retatrutide trials commonly excluded participants with a history of pancreatitis, medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2 (MEN 2), severe gastroparesis, recent major cardiovascular events, severe kidney impairment, type 1 diabetes (in the obesity studies), and pregnancy or breastfeeding

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Cost per month without insurance: $2,801 Cost per month with 80% coverage: $560 Outpatient (Non-Methadone): average total cost for a 4.5-month treatment period without insurance is $4,769