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In chronic cases, they can last for months or even yearsespecially when inflammation, muscle tension, or disc damage is left unresolved

There is no canonical receptor-binding motif in the sequence no signature that aligns with known opioid, melanocortin, GHS, GABA-modulatory or other established neuropeptide receptor families

This suggests any 503B requires very close regulatory scrutiny, and that role of 503Bs our drug supply as makers of medicines for last resort is entirely appropriate and should not be expanded

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