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ChaC1 overexpression can augment apoptosis by activating caspase-3/9, degradation of poly (ADP ribose) polymerase, induction of autophagy, ROS generation, increased intracellular calcium and loss of mitochondrial membrane potential (69)

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Composed of three amino acidscysteine, glutamate, and glycineglutathione is found in every cell of the body and is pivotal in neutralizing free radicals, thereby protecting against oxidative stress

Has generated a substantial translational research programme characterising MC1R-mediated photoprotection mechanisms that extends the compounds research relevance beyond basic pigmentation biology to covering UV-independent photoprotection research, DNA damage prevention biology, and the molecular mechanisms through which MC1R activation confers protection against UV-induced skin damage independent of melanin pigmentation itself

PMID: 22482077

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