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For example, after 4 weeks of wheel running, the expression of BDNF in the ipsilateral cerebral cortex was significantly increased compared with the control group [88], resulting in increased synaptic plasticity, improved cognitive function and motor function after TBI, reduced TBI-induced damage to the hippocampus, cortex, and thalamus, and decreased neuronal apoptosis, suggesting that exercise preconditioning can increase the secretion of BDNF in brain tissue to exert protective effects on neurons after TBI

Chapman JR & Roberts DW (1984) Humoral immune dysfunction as a result of prenatal exposure to diphenylhydantoin: correlation with the occurrence of physical defects

In addition, it supports gastrointestinal maturation, maintains intestinal mucosal integrity, ensures appropriate enzymatic activity, and contributes to host immune defense by regulating local immune responses

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doi: 10.1038/s41577-019-0127-6 4 ShiJXiaoWLiuYFuXPengM

7c), suggesting the epigenetic association between GSH and vitamin D metabolism genes