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Notably, vasorelaxation was abolished entirely when PI3K or NO synthase inhibitors were applied, confirming the critical role of this pathway (Masodsai et al., 2019)

Although patients with type 2 diabetes are a patient group in which the risk of major congenital malformations is higher than the general population, these studies present the first results on the risk of major congenital malformation after periconceptional GLP-1 RA exposure in women (Dolk et al

N Engl J Med (2011) 364:82941

on Sertoli cells, which physically support and nourish developing sperm

doi: 10.1016/j.jtemb.2015.07.002 109 KocakMAkarsuEKorkmazHTaysiS

Its discovery, published in Cell Metabolism (Lee et al., 2015), established it as a key regulator of glucose metabolism and insulin sensitivity