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No, a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) is an absolute contraindication to GLP-1 and dual GIP/GLP-1 receptor agonists

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An alternative mechanism is that synaptic space in the PVH of Lep ob/ob mice, vacated by the reduction in AgRP afferents, may become occupied by the elevated number of convergent GLP-1 inputs in these mice

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