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Achieving nearly 30% weight loss with a medication challenges previous assumptions about the upper limits of drug-induced weight reduction and brings us closer to the efficacy seen with bariatric surgery (30-40% weight loss), but without the surgical risks and recovery time

As semaglutide reduces body fat, less testosterone gets converted to estrogen, meaning fat loss may help restore healthier testosterone levels over time

doi:10.1161/CIRCULATIONAHA.111.033126 Stone GW, Kappetein AP, Sabik JF, et al

High sensitivity c-reactive protein, which is a marker of cardiovascular risk, got better

Great tasting

Starting orforglipron at a full maintenance dose immediately after discontinuing the injectable could produce excessive GLP-1 receptor stimulation and amplified GI side effects