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Individuals with NQO1 genetic variants (particularly the C609T/Pro187Ser polymorphism) have reduced ability to maintain ubiquinol levels, which compromises both mitochondrial function and membrane antioxidant defense

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Now, thats a meaningful step up from prior expectations and it reflects a shift from early adoption to a much broader, more scalable opportunity

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This may also explain the suboptimal response to gastric band intervention in both groups in terms of body weight and glycaemic response

Hakkinen et al., 2000), i.e., ~1 nmol.L 1 in young vs