Lose fat rapidly and GLP-1s can drive significant fat loss, sometimes 20% or more of total body weight and you reduce that source
J Basic Clin Physiol Pharmacol 35(6):325334 Rooks D, Swan T, Goswami B, Filosa LA, Bunte O, Panchaud N, Coleman LA, Miller RR, Garayoa EG, Praestgaard J (2020) Bimagrumab vs optimized standard of care for treatment of sarcopenia in community-dwelling older adults: a randomized clinical trial
Description Dihexa (PNB-0408) is a synthetic oligopeptide derived from angiotensin IV, studied as a potent activator of the hepatocyte growth factor / c-Met receptor signaling system
Before prescribing, I also make sure you have no contraindications to the particular medication prescribed, such as a history of pancreatitis, a personal or family history of a rare form of thyroid cancer called medullary thyroid cancer, or multiple endocrine neoplasia type 2
Conversely, the most recent systematic review and network meta-analysis from 2025 by Oliva et al [23], including 13 RCTs and 1,362 patients with bipolar depression, concluded that: although some evidence of increased risk of switching to mania was observed, no antidepressant was associated with a significantly higher risk of switch to mania compared to placebo
Weight management implications: If taking tirzepatide primarily for weight management, discuss how the temporary interruption may affect your progress and whether any additional support or dietary guidance is needed during the perioperative period
