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Some patients report fatigue during tirzepatide treatment, particularly during the early treatment phase or with dose escalation, though this is not among the most common adverse events in clinical trials

Tirzepatide targets the GLP-1 receptor and another hormone called GIP

Ozempic is only licensed as a type 2 diabetes treatment, although its been gaining attention online as a weight loss treatment because it contains semaglutide (the same active ingredient as Wegovy)

[1] [2] Individual gastrointestinal sensitivity: Patients with pre-existing gastrointestinal conditions such as gastroparesis, irritable bowel syndrome, or functional dyspepsia may experience earlier and more severe symptoms

The CDC has been collecting comparable data for 45 years