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Kotecha designed the Refine Her program to give women with complex conditions like PMOS the comprehensive, physician-led care they deserve treating the whole woman, not just one symptom at a time

Obesity is a major part of the problem, its complications including chronic kidney disease, hypertensive disease, stroke, and liver disease negatively impacting quality but also quantity of life as life expectancy decreases as body mass index (BMI) increases [3]

Pickart, Loren, and Anna Margolina

People taking other AMPK-activating drugs such as metformin, thiazolidinediones, or aspirin without prescriber input, because of theoretical overlap

There is a lack of known adverse effects

The FDA Adverse Event Reporting System (FAERS), a pharmacovigilance database maintained by the U.S