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Notably, the hydroxyl group at the C4 position of the tetrahydropyran ring of substrate 7 also stabilizes the GSH-thiolate through an additional hydrogen bond (Extended Data Fig

4.2 Real-world evidence: signal strength and heterogeneity of evidence Real-world evidence is derived primarily from spontaneous reporting systems and cohort studies

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Clinical trial meta-analyses have shown that weight loss resulting from dietary interventions and increased physical activity in patients with psoriasis significantly reduces the severity of disease symptoms (212, 213)

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