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Keywords: Type 2 diabetes, Semaglutide, Effectiveness, Treatment satisfaction, Eating behaviors HbA1c, Weight, Hyperglycemia, Non-HDL cholesterol Introduction Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by hyperglycemia caused by insulin resistance and deficiency of insulin secretion by the beta cells of the pancreas [1]

It helps regulate appetite and blood sugar by signaling fullness, slowing stomach emptying, and supporting insulin response

It regulates metabolic functions throughout the body

Long story short, I started Retatrutide at 4mg and worked my way up to 8mg over about ten weeks

However, the maximal pAKT and pERK were significantly lower at the E354Q variant compared to the WT receptor for GIP(1-42) and GIP(1-30)NH2

Pi-Sunyer X, Astrup A, Fujioka K, Greenway F, Halpern A, Krempf M, Lau DC, le Roux CW, Violante Ortiz R, Jensen CB, Wilding JP