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doi: 10.1186/s13045-022-01392-3 145 TongYWuYMaJIkedaMIdeTGriffinCTet al

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This cascade is conserved across many neurological disorders

They do not differ in the fundamental constraint: molecules above roughly 500 daltons don't cross intact stratum corneum passively, and the botanicals that do fit under that threshold arrive at doses two to three orders of magnitude below anything studied