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Small Animal Pract

Notably, proteins consistently altered in both human serum and mouse brain (P4HB, C1QA, CDH13) form a High-Confidence Translational Core, suggesting their central role in THCs therapeutic mechanism beyond species- or compartment-specific noise

This is directly related to the higher content of tryptophan and tyrosine in high-biological-value proteins, which support neurotransmitter synthesis (31)

Mechanistically, it has been observed that GSTP1-1 binds, in its monomeric form, both c-Jun and JNK, thus forming an heterotrimeric complex that inhibits the phosphorylation of c-Jun by JNK

When those instructions are corrupted, cells lose their ability to regulate themselves properly

doi:10.1016/j.fertnstert.2018.08.021 El Sharkwy I, Sharaf El-Din M