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The mechanism involves sympathetic nervous system activation and direct stimulation of gut hormone release

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Help absorb fat-soluble vitamins (A, D, E, and K)

A five-month treatment with PEGylated exenatide (NLY01) was found to decrease the secretion of complement 1q (C1q), IL-1, and TNF- by primary mouse microglia, thereby limiting the conversion of astrocytes to a neurotoxic phenotype

Retatrutide alone produced nausea in 38.1-43.2% of TRIUMPH-4 participants and discontinuation in 12.2-18.2% across the 9 mg and 12 mg arms

Vilarrasa E, Nicolau J, de la Cueva P, Goday A, Gallardo F, Martorell A, et al