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Treatment should only be continued if there is a beneficial metabolic response (reduction of at least 11 mmol/mol [1%] in HbA1c and weight loss of at least 3% of initial body weight at 6 months)

Lentigo maligna can undergo malignant transformation to lentigo maligna melanoma, and can manifest as increasingly dark pigmentation, color variegation, development of an elevated area, increase in size, and increased border irregularity

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