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GLP-1 medications have exploded in popularity to manage type 2 diabetes and treat obesity

Summary: Retatrutide can cause a dose-dependent increase in resting heart rate, with Phase 2 trials reporting mean rises of approximately 5 to 7 beats per minute at higher doses, likely driven by its GLP-1 and glucagon receptor agonism

Over a year, that 60-100 calorie daily deficit represents 6-10 pounds of potential weight loss or, conversely, 6-10 pounds of easier weight regain during a drug holiday

When to seek immediate medical care for GLP-1 side effects Most GLP-1 side effects arent serious

Concurrent use with insulin or sulfonylureas increases hypoglycaemia risk and may require dose adjustments of these medications