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10.3390/biomedicines10092059 6 BrennerJ

If calorie intake drops too quickly, you may feel: Low energy Weakness Lightheadedness This isnt the medication causing fatigue directlyits often under-fueling

Most prescribers recommend staying at this dose longer (68 weeks) rather than advancing, allowing full tolerance before escalation

These findings suggest that LAC may serve as a candidate biomarker to help diagnose a clinical endophenotype of MDD characterized by decreased LAC, greater severity, and earlier onset as well as a history of childhood trauma in patients with TRD

Patients still need options, and there are still ways to provide them with high-quality care

Santos LF, Silva AS, Mano JF