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Some common side effects include nausea, vomiting, diarrhea, and abdominal discomfort, especially when starting the treatment

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These patterns have led many scientists to frame AD as a brain-specific insulin-resistant state , colloquially type 3 diabetes. While not every expert embraces the term, multiple recent reviews detail the mechanistic links

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Diabetes is a major contributor to morbidity and mortality among people in Australia

For example, a GWAS study in European populations identified that the 15q25.1 locus variation in the CHRNA5 gene (such as rs55781567) significantly increases lung cancer risk, but only in individuals who have smoked previously