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Serum B12, methylmalonic acid, and homocysteine directly reflect B12 status and methylation capacity

J Braz Chem Soc

1g) that was suggestive of perturbed hepatic glutathione homeostasis

Immune Function : Glutathione is essential for maintaining a healthy immune response

By contrast, drugs that target metabolic pathways (e.g., GLUT1 inhibitors, PPP inhibitors, PDK inhibitors, and glutaminase inhibitors) may provide promising efficacy in ovarian cancer cells harboring nutrient addiction

Elevation of homocysteine arises from reduced activity of methionine synthase, a vitamin B 12 -dependent enzyme, however, this does not increase GSH biosynthesis