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Two cups of coffee that were fine at 250 pounds might overstimulate at 200 pounds

Schoen RE, et al

In Phase 2 research reported in The New England Journal of Medicine , participants began treatment with a low introductory dose, typically between 2 and 4 mg per week, and gradually increased to target doses ranging from 8 to 12 mg over several weeks

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Similar findings were observed in a randomized placebo-controlled trial where Zinc sulfate prevented the radiation-induced taste changes in head/neck cancer patients (Najafizade et al., 2013)

However, it turns out that when released, this protein also slows down gastric emptying