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10.1074/jbc.271.32.19298
The resulting elevated concentrations of homocysteine and MMA are often found in patients with low serum vitamin B 12 and can usually be lowered with successful vitamin B 12 replacement therapy
Injection site rotation prevents local tissue irritation and ensures consistent absorption
Likewise, also important for multiple sclerosis therapy, natalizumab also carries a specific risk of progressive multifocal leucoencephalopathy and reactivation of JC virus infection (24)
It activates VEGFR2 (vascular endothelial growth factor receptor 2), triggering the PI3K-Akt-eNOS cascade and elevating nitric oxide production
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