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However, head-to-head data comparing the drugs in routine practice remain limited, particularly among people without diabetes or established cardiovascular disease

It's a harm-reduction strategy for patients who have failed standard management and have a specific nausea pattern (acute, peak-dependent) that splitting might address

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Where the benefit is included, prior authorization is required: typically BMI 30 or higher, or BMI 27 or higher with a weight-related comorbidity (hypertension, type 2 diabetes, dyslipidemia, or obstructive sleep apnea), plus documented lifestyle program participation and weight-loss maintenance for renewal

Thats where Tirzepatide and Semaglutide come in