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Only one small study, undertaken in 100 women over only 8 weeks, looked at its use for management of perimenopausal symptoms, with significant reductions in menopause symptom scores noted.24Importantly, the Therapeutic Goods Association (TGA) issued a safety advisory for Withania somnifera in 2024 due to reports of severe gastrointestinal symptoms and liver damage in patients taking the herb, several of whom required hospitalisation.25 Use of medicines or herbal supplements containing Withania somnifera should be avoided in patients with existing or previous liver pathologies.25Non-herbal medicines and therapiesVitamin ETwo very small and short-term studies have shown that Vitamin E (800 iu per day for 4 weeks) decreased the number of hot flushes by 1 per day when used by women who have had breast cancer (n=120),26 and reduced the number of hot flushes by 2 per day in other women (400 iu vitamin E daily, n= 51).27Omega-3Use of Omega-3 showed no difference in the frequency and severity of hot flushes, insomnia severity, sleep quality compared to placebo in a systematic review and meta-analysis (n=183).28Supplementation with omega-3 can improve the lipid profile of postmenopausal women,29 and the Heart Foundation of Australia recommend fish oils as part of an adult diet to help lower the risk of coronary heart disease.30Cognitive behavioural therapy, hypnosis, yoga and non-prescription medicinesThe AMS information sheet Nonhormonal treatments for menopausal symptoms covers this.Compounded bioidentical menopausal hormone therapy (including progesterone cream)There is no evidence to support the efficacy or safety claims of compounded bioidentical hormones, or the superiority claims of these over conventional MHT

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DiDonato, J

J Food Biochem 45:e13545 Alfhili MA, Basudan AM, Aljaser FS, Dera A, Alsughayyir J (2021) Bioymifi, a novel mimetic of TNF-related apoptosis-induced ligand (TRAIL), stimulates eryptosis

Among the most frequent questions we hear is whether BPC-157 is truly the best peptide for gut healing, and what the science currently suggests about it

198 Several other studies examining the efficacy of neurofeedback for ADHD management concluded that it confers robust benefits for impulsivity and modest benefits for hyperactivity