In this context, two peptides have emerged as primary subjects of investigation, representing two fundamentally different approaches to reducing white adipose tissue (WAT) mass: HGH Fragment 176-191 and Adipotide
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The Phase 2b trial (PMID: 23714218) failed to demonstrate significant weight loss compared to placebo over 12 weeks, despite adequate sample size and dosing
The peptide does not compete for the hGH receptor, does not induce cell proliferation, and exerts direct effects on adipocyte metabolism without systemic endocrine disruption or IGF-1 elevation
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